MAXIMUM-LIKELIHOOD CRITERION AND SINGLE-MOLECULE DETECTION

被引：14
作者：
ENDERLEIN, J
机构：
[1] Gesellschaft zur Förderung der naturwissen-schaftlichen Forschung, Eingetragener Verein, Arbeitsgruppe Laser-diagnostik, Berlin, O-1199
来源：
APPLIED OPTICS | 1995年 / 34卷 / 03期
关键词：
FLUORESCENCE DETECTION; SINGLE-MOLECULE DETECTION; MAXIMUM LIKELIHOOD; TIME-CORRELATED SINGLE-PHOTON COUNTING;
D O I：
10.1364/AO.34.000514
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
The maximum-likelihood criterion is shown to be a powerful method for analyzing fluorescence-detection data with small signal-to-noise ratios. A probability study of the maximum-likelihood criterion for a supposed single-molecule detection experiment is presented that takes into account the photokinetics of the molecule to be detected, its diffusion, and the laser-beam geometry. Furthermore, the efficiency of time-integrated and time-correlated single-photon counting methods are studied and compared.
引用
收藏
页码：514 / 526
页数：13
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