A NOVEL METHOD TO FABRICATE BIOABSORBABLE SCAFFOLDS

被引：483
作者：
WHANG, K
THOMAS, CH
HEALY, KE
NUBER, G
机构：
[1] NORTHWESTERN UNIV, SCH DENT, DEPT BIOL MAT, CHICAGO, IL 60611 USA
[2] NORTHWESTERN UNIV, MCCORMICK SCH ENGN, DEPT BIOMED ENGN, EVANSTON, IL 60208 USA
[3] NORTHWESTERN UNIV, SCH MED, DEPT ORTHOPED SURG, CHICAGO, IL USA
来源：
POLYMER | 1995年 / 36卷 / 04期
关键词：
TISSUE ENGINEERING; BIOABSORBABLE POLYMERS; EMULSION PROCESSING;
D O I：
10.1016/0032-3861(95)93115-3
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 mu m (with larger pore diameters greater than 200 mu m), and specific pore area in the range 58-102 m(2) g(-1) were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.
引用
收藏
页码：837 / 842
页数：6
相关论文
共 29 条
[1]  
Adamson A. W., 1990, PHYSICAL CHEM SURFAC, P525
[2]   LOW-DENSITY, MICROCELLULAR POLYSTYRENE FOAMS [J].
AUBERT, JH ;
CLOUGH, RL .
POLYMER, 1985, 26 (13) :2047-2054
[3]   TISSUE ENGINEERING BY CELL TRANSPLANTATION USING DEGRADABLE POLYMER SUBSTRATES [J].
CIMA, LG ;
VACANTI, JP ;
VACANTI, C ;
INGBER, D ;
MOONEY, D ;
LANGER, R .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1991, 113 (02) :143-151
[4]   INVIVO OPTIMIZATION OF A LIVING DERMAL SUBSTITUTE EMPLOYING CULTURED HUMAN FIBROBLASTS ON A BIODEGRADABLE POLYGLYCOLIC ACID OR POLYGLACTIN MESH [J].
COOPER, ML ;
HANSBROUGH, JF ;
SPIELVOGEL, RL ;
COHEN, R ;
BARTEL, RL ;
NAUGHTON, G .
BIOMATERIALS, 1991, 12 (02) :243-248
[5]   DEGRADATION RATES OF POLYMERS AND COPOLYMERS OF POLYLACTIC AND POLYGLYCOLIC ACIDS [J].
CUTRIGHT, DE ;
PEREZ, B ;
BEASLEY, JD ;
LARSON, WJ ;
POSEY, WR .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1974, 37 (01) :142-152
[6]   EMULSION-DERIVED FOAMS - PREPARATION, PROPERTIES, AND APPLICATION [J].
EVEN, WR ;
GREGORY, DP .
MRS BULLETIN, 1994, 19 (04) :29-33
[7]  
EVERETT DH, 1989, BASIC PRINCIPLES COL, P115
[8]  
EVERETT DH, 1989, BASIC PRINCIPLES COL, P130
[9]   NEOCARTILAGE FORMATION INVITRO AND INVIVO USING CELLS CULTURED ON SYNTHETIC BIODEGRADABLE POLYMERS [J].
FREED, LE ;
MARQUIS, JC ;
NOHRIA, A ;
EMMANUAL, J ;
MIKOS, AG ;
LANGER, R .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1993, 27 (01) :11-23
[10]  
GOGOLEWSKI S, 1983, MAKROMOL CHEM-RAPID, V4, P675
123