FRACTIONATED TREATMENT OF CAD2 TUMORS IN MICE SENSITIZED WITH ALUMINUM PHTHLOCYANINE TETRASULFONATE

被引：9

作者：

ANHOLT, H ^{[1
]}

MOAN, J ^{[1
]}

机构：

[1] INST CANC RES, DEPT BIOPHYS, N-0310 OSLO 3, NORWAY

来源：

CANCER LETTERS | 1992年 / 61卷 / 03期

关键词：

PHOTOCHEMOTHERAPY; ALUMINUM PHTHALOCYANINE; MURINE TUMOR MODEL; FRACTIONATED TREATMENT;

D O I：

10.1016/0304-3835(92)90297-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CaD2 mammary carcinomas transplanted into the feet of mice were treated with tetrasulfonated phthalocyanine (AlPcS4) and laser light at 680 nm. A light dose of 135 J/cm2 was either given as continuous radiation (15 min) or fractionated with 15 s exposure, 15 s darkness, 15 s exposure and so on for 30 min. The CaD2 tumors were found to respond better to a fractionated exposure than to the same energy given in one exposure. The reason for this is assumed to be a relocalization of the dye upon illumination, seen as a rapid decrease in fluorescence. When the laser light was turned off, the fluorescence returned to almost the initial value.

引用

页码：263 / 267

页数：5

共 15 条

[1]

ANHOLT H, IN PRESS FLUORESCENC

[2]

BEGG AC, 1980, BRIT J CANCER, V41, P93

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