Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data

被引：20

作者：

Kim, Moon Young ^{[1
,2
,26
]}

Um, Soon Ho ^{[3
,26
]}

Baik, Soon Koo ^{[1
,2
,26
]}

Seo, Yeon Seok ^{[3
,26
]}

Park, Soo Young ^{[4
,26
]}

Lee, Jung Il ^{[5
,26
]}

Lee, Jin Woo ^{[5
,26
]}

Cheon, Gab Jin ^{[6
,26
]}

Sohn, Joo Hyun ^{[7
,26
]}

Kim, Tae Yeob ^{[7
,26
]}

Lim, Young Suk ^{[8
,26
]}

Kim, Tae Hyo ^{[9
,26
]}

Lee, Tae Hee ^{[10
,26
]}

Park, Sung Jae ^{[11
,26
]}

Park, Seung Ha ^{[11
,26
]}

Kim, Jin Dong ^{[12
,26
]}

Han, Sang Young ^{[13
,26
]}

Choi, Chang Soo ^{[14
,26
]}

Cho, Eun Young ^{[14
,26
]}

Kim, Dong Joon ^{[15
,26
]}

Hwang, Jae Seok ^{[16
,26
]}

Jang, Byoung Kuk ^{[16
,26
]}

Lee, June Sung ^{[17
,26
]}

Kim, Sang Gyune ^{[26
]}

Kim, Young Seok ^{[18
,26
]}

Kwon, So Young ^{[19
,26
]}

Choe, Won Hyeok ^{[19
,26
]}

Lee, Chang Hyeong ^{[20
,26
]}

Kim, Byung Seok ^{[20
,26
]}

Jang, Jae Young ^{[21
,26
]}

Jeong, Soung Won ^{[21
,26
]}

Kim, Byung Ho ^{[22
,26
]}

Shim, Jae Jun ^{[22
,26
]}

Cho, Yong Kyun ^{[23
,26
]}

Koh, Moon Soo ^{[24
,26
]}

Lee, Hyun Woong ^{[25
,26
]}

机构：

[1] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea

[2] Yonsei Univ, Wonju Coll Med, Cell Therapy & Tissue Engn Ctr, Wonju, South Korea

[3] Korea Univ, Coll Med, Dept Internal Med, 73 Inchon Ro, Seoul 136705, South Korea

[4] Kyungpook Natl Univ, Coll Med, Dept Internal Med, Daegu, South Korea

[5] Inha Univ, Coll Med, Dept Internal Med, Incheon, South Korea

[6] Ulsan Univ, Coll Med, Dept Internal Med, Kangnung, South Korea

[7] Hanyang Univ, Coll Med, Hanyang Univ Guri Hosp, Dept Internal Med, Guri, South Korea

[8] Ulsan Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[9] Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Jinju, South Korea

[10] Konyang Univ, Coll Med, Dept Internal Med, Daejeon, South Korea

[11] Inje Univ, Coll Med, Dept Internal Med, Busan, South Korea

[12] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea

[13] Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea

[14] Wonkwang Univ, Coll Med, Dept Internal Med, Iksan, South Korea

[15] Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea

[16] Keimyung Univ, Coll Med, Dept Internal Med, Daegu, South Korea

[17] Inje Univ, Coll Med, Dept Internal Med, Goyang, South Korea

[18] Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Hosp Bucheon, Dept Internal Med, Bucheon, South Korea

[19] Konkuk Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[20] Catholic Univ Daegu, Coll Med, Dept Internal Med, Daegu, South Korea

[21] Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Hosp Seoul, Dept Internal Med, Seoul, South Korea

[22] Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[23] Sungkyunkwan Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[24] Dongguk Univ, Coll Med, Dept Internal Med, Goyang, South Korea

[25] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[26] Korean Portal Hypertens Study Grp, Seoul, South Korea

来源：

CLINICAL AND MOLECULAR HEPATOLOGY | 2013年 / 19卷 / 01期

关键词：

Gastric variceal bleeding; Rebleeding; Mortality; Cirrhosis;

D O I：

10.3350/cmh.2013.19.1.36

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. Methods: The data of 1,308 episodes of GVB (males: females=1062: 246, age=55.0 +/- 11.0 years, mean +/- SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. Results: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [ odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child- Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). Conclusions: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.

引用

页码：36 / 44

页数：9

共 27 条

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