4-METHYLPYRAZOLE - A CONTROLLED-STUDY OF SAFETY IN HEALTHY-HUMAN SUBJECTS AFTER SINGLE, ASCENDING DOSES

被引：56
作者：
JACOBSEN, D
SEBASTIAN, CS
BLOMSTRAND, R
MCMARTIN, KE
机构：
[1] LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL,TOXICOL SECT,METAB ALCOHOL RES GRP,POB 33932,SHREVEPORT,LA 71130
[2] LOUISIANA STATE UNIV,DEPT PSYCHIAT,SHREVEPORT,LA 71130
[3] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT CLIN CHEM,S-14186 HUDDINGE,SWEDEN
来源：
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1988年 / 12卷 / 04期
关键词：
D O I：
10.1111/j.1530-0277.1988.tb00235.x
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
引用
收藏
页码：516 / 522
页数：7
相关论文
共 37 条
[1]  
BAUD FJ, 1987, J TOXICOL-CLIN TOXIC, V24, P463
[2]   BIOLOGICAL EFFECTS AND METABOLIC INTERACTIONS AFTER CHRONIC AND ACUTE ADMINISTRATION OF 4-METHYLPYRAZOLE AND ETHANOL TO RATS .1. [J].
BLOMSTRAND, R ;
ELLIN, A ;
LOF, A ;
OSTLINGWINTZELL, H .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1980, 199 (02) :591-605
[3]   NORMAL ELECTRORETINOGRAM AND NO TOXICITY SIGNS AFTER CHRONIC AND ACUTE ADMINISTRATION OF THE ALCOHOL-DEHYDROGENASE INHIBITOR 4-METHYLPYRAZOLE TO THE CYNOMOLGUS MONKEY (MACACA, FASCICULARIS) - A POSSIBLE NEW TREATMENT OF METHANOL POISONING [J].
BLOMSTRAND, R ;
INGEMANSSON, SO ;
JENSEN, M ;
HEDSTROM, CG .
DRUG AND ALCOHOL DEPENDENCE, 1984, 13 (01) :9-20
[4]   INHIBITORY EFFECT ON ETHANOL OXIDATION IN MAN AFTER ADMINISTRATION OF 4-METHYLPYRAZOLE [J].
BLOMSTRAND, R ;
THEORELL, H .
LIFE SCIENCES PT-2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1970, 9 (11) :631-+
[5]   STUDIES ON THE EFFECT OF 4-METHYLPYRAZOLE ON METHANOL POISONING USING THE MONKEY AS AN ANIMAL-MODEL - WITH PARTICULAR REFERENCE TO THE OCULAR TOXICITY [J].
BLOMSTRAND, R ;
INGEMANSSON, SO .
DRUG AND ALCOHOL DEPENDENCE, 1984, 13 (04) :343-355
[6]  
BODIN NO, 1969, T93 AB ASTR REP 1
[7]   METABOLIC-ACIDOSIS OF ETHYLENE-GLYCOL INTOXICATION [J].
CLAY, KL ;
MURPHY, RC .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 39 (01) :39-49
[8]   THE INHIBITION OF ALCOHOL-DEHYDROGENASE INVITRO AND IN ISOLATED HEPATOCYTES BY 4-SUBSTITUTED PYRAZOLES [J].
CORNELL, NW ;
HANSCH, C ;
KIM, KH ;
HENEGAR, K .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 227 (01) :81-90
[9]   INHIBITORY POWER OF SOME FURTHER PYRAZOLE DERIVATIVES OF HORSE LIVER ALCOHOL-DEHYDROGENASE [J].
DAHLBOM, R ;
TOLF, BR ;
AKESON, A ;
LUNDQUIST, G ;
THEORELL, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 57 (03) :549-553
[10]   THE D(V-K) ISOTOPE EFFECT OF THE CYTOCHROME P-450-MEDIATED OXIDATION OF ETHANOL AND ITS BIOLOGICAL APPLICATIONS [J].
DAMGAARD, SE .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 125 (03) :593-603
1234