ANTIOXIDANTS INCREASE THE FORMATION OF 6-OXO-PGF-1-ALPHA BY RAM SEMINAL-VESICLE MICROSOMES

被引：33

作者：

BEETENS, JR ^{[1
]}

CLAEYS, M ^{[1
]}

HERMAN, AG ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP, FAC MED, DIV PHARMACOL, B-2610 WILRIJK, BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1981年 / 30卷 / 20期

关键词：

D O I：

10.1016/0006-2952(81)90419-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of antioxidants on the conversion of arachidonic acid and prostaglandin endoperoxide H2 by ram seminal vesicle microsomes was investigated. The antioxidants ascorbic acid and propylgallate enhanced significantly the formation of 6-oxo-PGF1.alpha.. They shifted the pathway of the endoperoxide H2 from the non-enzymic decomposition to the enzymic formation of prostacyclin. Those antioxidants may partially act through neutralization of an oxidative species which is formed during the conversion of arachidonic acid. The other mechanisms through which they act remain to be elucidated.

引用

页码：2811 / 2815

页数：5

共 17 条

[1] SYNTHESIS OF 6-KETO-PGF1-ALPHA BY RAM SEMINAL-VESICLE MICROSOMES [J].

COTTEE, F ;

FLOWER, RJ ;

MONCADA, S ;

SALMON, JA ;

VANE, JR .

PROSTAGLANDINS, 1977, 14 (03) :413-423

[2]

DONATI MB, 1979, SEP INT S END PLAT P

[3]

EGAN RW, 1976, J BIOL CHEM, V251, P7329

[4] ARTERIAL-WALLS ARE PROTECTED AGAINST DEPOSITION OF PLATELET THROMBI BY A SUBSTANCE (PROSTAGLANDIN-X) WHICH THEY MAKE FROM PROSTAGLANDIN ENDOPEROXIDES [J].

GRYGLEWSKI, RJ ;

BUNTING, S ;

MONCADA, S ;

FLOWER, RJ ;

VANE, JR .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (05) :685-713

[5]

HAM EA, 1979, J BIOL CHEM, V254, P2191

[6] LIPIDS OF HUMAN ATHEROMA .8. OXIDIZED DERIVATIVES OF CHOLESTERYL LINOLEATE [J].

HARLAND, WA ;

GILBERT, JD ;

BROOKS, CJW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 316 (03) :378-385

[7] LIPOXYGENATION ACTIVITY OF PURIFIED PROSTAGLANDIN-FORMING CYCLOOXYGENASE [J].

HEMLER, ME ;

CRAWFORD, CG ;

LANDS, WEM .

BIOCHEMISTRY, 1978, 17 (09) :1772-1779

[8] ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, R ;

BUNTING, S ;

VANE, JR .

NATURE, 1976, 263 (5579) :663-665

[9] LIPID PEROXIDE INHIBITS ENZYME IN BLOOD-VESSEL MICROSOMES THAT GENERATES FROM PROSTAGLANDIN ENDOPEROXIDES SUBSTANCE (PROSTAGLANDIN-X) WHICH PREVENTS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, RJ ;

BUNTING, S ;

VANE, JR .

PROSTAGLANDINS, 1976, 12 (05) :715-737

[10] ARACHIDONATE-INDUCED THROMBOSIS IN VITAMIN-E-DEFICIENT RABBITS [J].

NAFSTAD, I .

TOXICOLOGY LETTERS, 1978, 2 (06) :313-318

← 1 2 →