SELECTINS

被引：240
作者：
MCEVER, RP
机构：
[1] University of Oklahoma, Oklahoma City
来源：
CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 01期
关键词：
D O I：
10.1016/0952-7915(94)90037-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The selectins are three related receptors that initiate rolling of leukocytes on activated platelets or endothelium through Ca2+-dependent recognition of cell surface carbohydrates. Cell adhesion may be enhanced by a limited number of membrane glycoproteins that present high affinity carbohydrate ligands to specific selectins. The synthesis and surface display of the selectins is normally tightly controlled, but inappropriate expression may contribute to inflammatory disorders. Recent in vivo studies confirm the importance of the selectins in both physiological and pathological leukocyte recruitment.
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页码：75 / 84
页数：10
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