The role of heat-shock proteins as molecular chaperones

被引：126

作者：

Welch, William J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Physiol & Med, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1991年 / 3卷 / 06期

关键词：

D O I：

10.1016/0955-0674(91)90125-I

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have revealed that protein folding and assembly events in vivo require the participation of accessory components, now being referred to as 'molecular chaperones'. A number of chaperones have been identified as members of the heat-shock (or stress) protein family. This review discusses the roles of two classes of chaperones, the heat-shock protein 70 and groEL/ES families, in facilitating protein maturation, and describes how such events are perturbed in the cell subjected to metabolic stress.

引用

页码：1033 / 1038

页数：6

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