The role of heat-shock proteins as molecular chaperones

被引：126

作者：

Welch, William J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Physiol & Med, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1991年 / 3卷 / 06期

关键词：

D O I：

10.1016/0955-0674(91)90125-I

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have revealed that protein folding and assembly events in vivo require the participation of accessory components, now being referred to as 'molecular chaperones'. A number of chaperones have been identified as members of the heat-shock (or stress) protein family. This review discusses the roles of two classes of chaperones, the heat-shock protein 70 and groEL/ES families, in facilitating protein maturation, and describes how such events are perturbed in the cell subjected to metabolic stress.

引用

页码：1033 / 1038

页数：6

共 22 条

[1]

ANATHAN J, 1986, SCIENCE, V232, P252

[2] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS [J].

ANFINSEN, CB .

SCIENCE, 1973, 181 (4096) :223-230

[3] INTERACTION OF HSP-70 WITH NEWLY SYNTHESIZED PROTEINS - IMPLICATIONS FOR PROTEIN FOLDING AND ASSEMBLY [J].

BECKMANN, RP ;

MIZZEN, LA ;

WELCH, WJ .

SCIENCE, 1990, 248 (4957) :850-854

[4] MITOCHONDRIAL HEAT-SHOCK PROTEIN HSP60 IS ESSENTIAL FOR ASSEMBLY OF PROTEINS IMPORTED INTO YEAST MITOCHONDRIA [J].

CHENG, MY ;

HARTL, FU ;

MARTIN, J ;

POLLOCK, RA ;

KALOUSEK, F ;

NEUPERT, W ;

HALLBERG, EM ;

HALLBERG, RL ;

HORWICH, AL .

NATURE, 1989, 337 (6208) :620-625

[5]

CHIANG HL, 1989, SCIENCE, V246, P381

[6] MOLECULAR CHAPERONES [J].

ELLIS, RJ ;

VANDERVIES, SM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :321-347

[7] SIMILARITY OF THE 3-DIMENSIONAL STRUCTURES OF ACTIN AND THE ATPASE FRAGMENT OF A 70-KDA HEAT-SHOCK COGNATE PROTEIN [J].

FLAHERTY, KM ;

MCKAY, DB ;

KABSCH, W ;

HOLMES, KC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :5041-5045

[8] PEPTIDE BINDING AND RELEASE BY PROTEINS IMPLICATED AS CATALYSTS OF PROTEIN ASSEMBLY [J].

FLYNN, GC ;

CHAPPELL, TG ;

ROTHMAN, JE .

SCIENCE, 1989, 245 (4916) :385-390

[9] RENATURATION OF DENATURED-LAMBDA REPRESSOR REQUIRES HEAT-SHOCK PROTEINS [J].

GAITANARIS, GA ;

PAPAVASSILIOU, AG ;

RUBOCK, P ;

SILVERSTEIN, SJ ;

GOTTESMAN, ME .

CELL, 1990, 61 (06) :1013-1020

[10]

GOLOUBINOFF P, 1989, NATURE, V342, P884

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