AMINO-ACID-METABOLISM ENZYME-ACTIVITIES IN THE OBESE ZUCKER RAT

被引:0
作者
DOMENECH, M [1 ]
LOPEZSORIANO, FJ [1 ]
MARZABAL, M [1 ]
ARGILES, JM [1 ]
机构
[1] UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & FISIOL,DIAGONAL 645,E-08071 BARCELONA,SPAIN
关键词
ZUCKER RAT; AMINO ACID METABOLISM; ENZYME ACTIVITIES; OBESITY;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hepatic serine dehydratase activity was significantly lower in the obese Zucker rats. In both skeletal muscle and kidney adenylate deaminase showed a lower activity in the obese animals. In the small intestine the activity of glutamate dehydrogenase was increased while that of glutamine synthetase was reduced. No changes were found in the enzymatic activities of white adipose tissue while those found in brown adipose tissue were lower for glutamine synthetase. Starvation resulted in increase in liver serine dehydratase in the lean animals and in aspartate transaminase in both lean and obese. Kidney aspartate transaminase and glutamine synthetase were increased with starvation in the lean rats while kidney adenylate deaminase and small intestine glutamine synthetase and branched-chain amino acid transaminase were increased with starvation in the obese animals. In brown adipose tissue starvation caused an increase in branched-chain amino acid transaminase in the lean rats while it significantly lowered the adenylate deaminase and increased branched-chain amino acid transaminase in the obese rats.
引用
收藏
页码:405 / 414
页数:10
相关论文
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