MICROWAVE IRRADIATION OF RATS AT 2.45 GHZ ACTIVATES PINOCYTOTIC-LIKE UPTAKE OF TRACER BY CAPILLARY ENDOTHELIAL-CELLS OF CEREBRAL-CORTEX

Far-field exposures of male albino rats to 2.45-GHz microwaves (10-mu-sec pulses, 100 pps) at a low average power density (10 mW/cm2; SAR approximately 2 W/kg) and short durations (30-120 min) resulted in increased uptakes of tracer through the blood-brain barrier (BBB). The uptake of systemically administered rhodamine-ferritin complex by capillary endothelial cells (CECs) of the cerebral cortex was dependent on power density and on duration of exposure. At 5 mW/cm2, for example, a 15-min exposure had no effect. Near-complete blockade of uptake resulted when rats were treated before exposure to microwaves with a single dose of colchicine, which inhibits microtubular function. A pinocytotic-like mechanism is presumed responsible for the microwave-induced increase in BBB permeability.