H3Africa multi-centre study of the prevalence and environmental and genetic determinants of type 2 diabetes in sub-Saharan Africa: study protocol

被引：13

作者：

Ekoru, K. ^{[1
,2
]}

Young, E. H. ^{[1
,2
]}

Adebamowo, C. ^{[3
,4
,5
]}

Balde, N. ^{[6
]}

Hennig, B. J. ^{[7
,8
]}

Kaleebu, P. ^{[9
]}

Kapiga, S. ^{[10
,11
]}

Levitt, N. S. ^{[12
]}

Mayige, M. ^{[13
]}

Mbanya, J. C. ^{[14
]}

McCarthy, M. I. ^{[15
,16
,17
]}

Nyan, O. ^{[18
]}

Nyirenda, M. ^{[19
]}

Oli, J. ^{[11
]}

Ramaiya, K. ^{[20
]}

Smeeth, L. ^{[21
]}

Sobngwi, E. ^{[14
]}

Rotimi, C. N. ^{[22
]}

Sandhu, M. S. ^{[1
,2
]}

Motala, A. A. ^{[23
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge, England

[2] Wellcome Trust Sanger Inst, Genet Epidemiol Grp, Cambridge, England

[3] Inst Human Virol, Abuja, Nigeria

[4] Univ Maryland Baltimore, Sch Med, Dept Epidemiol & Publ Hlth, Inst Human Virol, Baltimore, MD USA

[5] Univ Maryland Baltimore, Sch Med, Greenebaum Canc Ctr, Baltimore, MD USA

[6] Univ Conakry, Non Communicable Dis Unit, CHU Donka, Minist Hlth, Conackry, Guinea

[7] MRC Keneba, MRC Unit, MRC Int Nutr Grp, Keneba, Gambia

[8] London Sch Hyg & Trop Med, MRC Int Nutr Grp, London, England

[9] MRC UVRI Uganda Res Unit AIDS, Entebbe, Uganda

[10] Mwanza Intervent Trials Unit NIMR, Mwanza, Tanzania

[11] Univ Nigeria, Teaching Hosp, Enugu, Nigeria

[12] Univ Cape Town, Dept Med, Div Diabet Med & Endocrinol, Chron Dis Initiat Africa, Cape Town, South Africa

[13] Natl Inst Med Res, Dar Es Salaam, Tanzania

[14] Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon

[15] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Churchill Hosp, Old Rd, Oxford, England

[16] Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford, England

[17] Churchill Hosp, Oxford NIHR Biomed Res Ctr, Old Rd, Oxford, England

[18] Univ Gambia, Sch Med, Edward Francis Small Teaching Hosp, Banjul, Gambia

[19] Malawi Epidemiol & Intervent Res Unit, Lilongwe, Malawi

[20] Muhimbili Univ Hlth & Allied Sci, Dept Med, Dar Es Salaam, Tanzania

[21] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London, England

[22] NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

[23] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Endocrinol & Diabet, Durban, South Africa

来源：

GLOBAL HEALTH EPIDEMIOLOGY AND GENOMICS | 2016年 / 1卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Epidemiology; genetics; H3Africa; sub-Saharan Africa; type; 2; diabetes;

D O I：

10.1017/gheg.2015.6

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The burden and aetiology of type 2 diabetes (T2D) and its microvascular complications may be influenced by varying behavioural and lifestyle environments as well as by genetic susceptibility. These aspects of the epidemiology of T2D have not been reliably clarified in sub-Saharan Africa (SSA), highlighting the need for context-specific epidemiological studies with the statistical resolution to inform potential preventative and therapeutic strategies. Therefore, as part of the Human Heredity and Health in Africa (H3Africa) initiative, we designed a multi-site study comprising case collections and population-based surveys at 11 sites in eight countries across SSA. The goal is to recruit up to 6000 T2D participants and 6000 control participants. We will collect questionnaire data, biophysical measurements and biological samples for chronic disease traits, risk factors and genetic data on all study participants. Through integrating epidemiological and genomic techniques, the study provides a framework for assessing the burden, spectrum and environmental and genetic risk factors for T2D and its complications across SSA. With established mechanisms for fieldwork, data and sample collection and management, data-sharing and consent for re-approaching participants, the study will be a resource for future research studies, including longitudinal studies, prospective case ascertainment of incident disease and interventional studies.

引用

页数：12

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