GLUCOCORTICOID REGULATION OF CANNABINOID RECEPTOR MESSENGER-RNA LEVELS IN THE RAT CAUDATE-PUTAMEN - AN IN-SITU HYBRIDIZATION STUDY

被引：44
作者：
MAILLEUX, P
VANDERHAEGHEN, JJ
机构：
[1] Laboratory of Neurosciences, Université Libre de Bruxelles, Bruxelles
来源：
NEUROSCIENCE LETTERS | 1993年 / 156卷 / 1-2期
关键词：
MARIJUANA; CANNABIS; DELTA-9-TETRAHYDROCANNABINOL; ADRENALECTOMY; BRAIN;
D O I：
10.1016/0304-3940(93)90437-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The influence of adrenalectomy on cannabinoid receptor gene expression in the adult rat dorsal striatum was investigated by in situ hybridization with specific oligonucleotide probes. The caudate-putamen of adrenalectomized rats contains approximately 50% significantly higher mRNA levels than the controls. This increase could be counteracted by dexamethasone treatment. Together, these results suggest glucocorticoid down-regulation of cannabinoid receptor gene expression in the striatum.
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页码：51 / 53
页数：3
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