CYTOKINES AND CANCER - EXPERIMENTAL SYSTEMS

被引：56

作者：

BLANKENSTEIN, T ^{[1
]}

ROWLEY, DA ^{[1
]}

SCHREIBER, H ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL 60637

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 05期

关键词：

D O I：

10.1016/0952-7915(91)90098-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transfer of certain cytokine genes into cancer cells can provide very powerful suppression of tumor growth in the absence of any toxic side effects. Some of these cytokines, such as interleukin-4, granulocyte colony-stimulating factor and tumor necrosis factor, can mediate powerful immune suppression even in T-cell-deficient animals and appear to be effective for poorly or non-antigenic tumors. However, approaches must be found to induce or deliver cytokines locally at the tumor site.

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页码：694 / 698

页数：5

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