COMPARISON OF INOTROPIC AND CHRONOTROPIC RESPONSES IN RAT ISOLATED ATRIA AND VENTRICLES

被引：15

作者：

BROWN, L ^{[1
]}

SERNIA, C ^{[1
]}

NEWLING, R ^{[1
]}

FLETCHER, P ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT MED,SYDNEY,NSW 2006,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1991年 / 18卷 / 11期

关键词：

ADRENOCEPTORS; CHRONOTROPY; INOTROPY; RAT HEART;

D O I：

10.1111/j.1440-1681.1991.tb01393.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The positive inotropic and chronotropic responses to adrenoceptor agonists (noradrenaline, phenylcphrine), to compounds which increase cAMP by post-adrenoceptor mechanisms (forskolin, theophylline and dibutyryl cAMP) and to calcium chloride were measured in isolated rat atria and papillary muscles from both ventricles. 2. Noradrenaline produced similar maximal inotropic responses to calcium chloride in all tissues. Forskolin gave similar responses to calcium chloride in atrial but not ventricular tissues; the reverse was observed with dibutyryl cAMP. Phenylephrine and theophylline produced significantly smaller inotropic responses than calcium chloride in all tissues, especially in ventricular tissues. 3. Maximal chronotropic responses to noradrenaline, theophylline and dibutyryl cAMP were similar. Forskolin produced significantly greater responses while calcium chloride and phenylephrine produced significantly smaller responses than noradrenaline. 4. These results show that the maximal positive inotropic response of some agonists is markedly dependent on the tissue chosen. Further, chronotropic responses in right atria do not mimic inotropic responses in left atria.

引用

页码：753 / 760

页数：8

共 23 条

[1] CHARACTERIZATION OF THE CARDIOTONIC EFFECTS OF MILRINONE, A NEW AND POTENT CARDIAC BIPYRIDINE, ON ISOLATED-TISSUES FROM SEVERAL ANIMAL SPECIES [J].