Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

被引：4

作者：

Patil, Harshal S. ^{[1
]}

Jadhav, Dipesh D. ^{[1
]}

Paul, Ajay ^{[1
]}

Mulani, Fayaj A. ^{[1
,2
]}

Karegaonkar, Shrikant J. ^{[1
,2
]}

Thulasiram, Hirekodathakallu V. ^{[1
,2
,3
]}

机构：

[1] CSIR, Div Organ Chem, Chem Biol Unit, Natl Chem Lab, Pune 411008, Maharashtra, India

[2] Acad Sci & Innovat Res, 2 Rafi Marg, New Delhi 110001, India

[3] CSIR, Inst Gen & Integrat Biol, Mall Road, New Delhi 110001, India

来源：

DATA IN BRIEF | 2018年 / 18卷

关键词：

Andrographolide; Lipase; Antimicrobial;

D O I：

10.1016/j.dib.2018.03.103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide. (C) 2018 Published by Elsevier Inc.

引用

页码：1134 / 1141

页数：8

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