INVITRO ACTIVITY OF BAY V-3522, A NEW ORAL CEPHALOSPORIN

The in vitro activity of BAY v 3522 was compared with the activities of cephalexin, cefaclor, cefuroxime, cefixime, and amoxicillin-clavulanate. MICs (in μg/ml) of BAY v 3522 were as follows: Staphylococcus spp. (except for oxacillin-resistant strains), 0.13 to 1; Streptococcus spp. (except for some viridans group streptococci), ≤ 0.015 to 0.25; Enterococcus faecalis, 2 to 8; other enterococci, 0.5 to > 32; β-lactamase-negative Haemophilus influenzae and Branhamella catarrhalis, 0.13 to 1; β-lactamase-positive H. influenzae and B. catarrhalis, 0.5 to 4; Pasteurella multocida, 0.06 to 0.25; and members of the family Enterobacteriaceae, 0.5 to < 32. Among the cephalosporins, BAY v 3522 was the most active against gram-positive cocci and cefixime was the most active against gram-negative bacilli; BAY v 3522 was similar in activity to amoxicillin-clavulanate against most species.