CSF SOMATOSTATIN IN CHILDHOOD PSYCHIATRIC-DISORDERS - A PRELIMINARY INVESTIGATION

被引：22

作者：

KRUESI, MJP ^{[1
]}

SWEDO, S ^{[1
]}

LEONARD, H ^{[1
]}

RUBINOW, DR ^{[1
]}

RAPOPORT, JL ^{[1
]}

机构：

[1] NIMH, INTRAMURAL RES PROGRAM, BETHESDA, MD 20892 USA

来源：

PSYCHIATRY RESEARCH | 1990年 / 33卷 / 03期

关键词：

Somatostatin; conduct disorder; obsessive-compulsive disorder; depression; somatotype;

D O I：

10.1016/0165-1781(90)90044-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Disruptive behavior disorders and obsessive-compulsive disorder have been associated with serotonergic dysfunction as well as particular body habitus findings in pediatric patients. Somatostatin, a peptide which stimulates serotonin release and inhibits growth hormone release, was measured in the cerebrospinal fluid (CSF) of 10 children with disruptive behavior disorders and in 10 age-, sex-, and race-matched pairs of obsessive-compulsive disorder patients. Decreased concentrations of somatostatin were found in disruptive behavior disorder patients relative to obsessive-compulsive children, even after controlling for differences in Tanner stage. In contrast to studies in adults, those patients in a depressed state did not have lower CSF somatostatin concentration. © 1990.

引用

页码：277 / 284

页数：8

共 56 条

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ACHENBACH TM, 1983, MANUAL CHILD BEHAVIO

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