DECREASE IN CYTOKINE PRODUCTION BY HIV-INFECTED MACROPHAGES IN RESPONSE TO LPS-MEDIATED ACTIVATION

被引:0
作者
TSAI, WP
HIROSE, K
NARA, PL
KUANG, YD
CONLEY, S
LI, BQ
KUNG, HF
MATSUSHIMA, K
机构
[1] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702
[2] NCI,FREDERICK CANC RES & DEV CTR,PRI,DYNCORP,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD 21702
[3] RES INST,DEPT PHARMACOL,KANAZAWA 920,JAPAN
[4] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC ETIOL,TUMOR CELL BIOL LAB,FREDERICK,MD 21702
来源
LYMPHOKINE AND CYTOKINE RESEARCH | 1991年 / 10卷 / 06期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The capacity of human monocytes/macrophages (M/M) infected with a human immunodeficiency virus-1 (HIV-1) isolate to produce several immunomodulating cytokines including interleukin-1-alpha (IL-1-alpha), IL-1-beta, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-8, and macrophage chemoattractant and activating factor (MCAF) was examined. Although HIV infection itself induced significant increases in the level of mRNAs for IL-1-beta, TNF-alpha, IL-6, and IL-8, the levels of lipopolysaccharide (LPS)-induced mRNAs for IL-1-alpha, IL-1-beta, TNF-alpha, IL-6, IL-8, and MCAF were decreased over those of uninfected LPS-stimulated cells. In addition, HIV-infected M/M produced lower amounts of IL-8 protein, as measured by radioimmunoassay over an 18-day culture period. These results suggest that HIV infection generally suppresses the LPS-inducible cytokine production in human M/M. The impact of the role of these cytokines in the immunity and pathogenesis of HIV-1 infection is discussed.
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页码:421 / 429
页数:9
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