CYTOPROTECTIVE EFFECTS OF CALCIUM-CHANNEL BLOCKERS - MECHANISMS AND POTENTIAL APPLICATIONS IN HEPATOCELLULAR INJURY

被引：26

作者：

DEAKIN, CD ^{[1
]}

FAGAN, EA ^{[1
]}

WILLIAMS, R ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL HOSP,INST LIVER STUDIES,DENMARK HILL,LONDON SE5 8RX,ENGLAND

来源：

JOURNAL OF HEPATOLOGY | 1991年 / 12卷 / 02期

关键词：

D O I：

10.1016/0168-8278(91)90947-A

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Deregulation of calcium homeostasis is strongly implicated in the development of cellular injury, including in hepatocytes, and is thought to be the limiting step in transition to an irreversible stage. Calcium channel blockers appear to exert their cytoprotective effects through several mechanisms. These may involve blockade of L-(long-lasting)-type calcium channels, reduction of oxidative stress, antagonism at inflammatory mediator receptor sites and interaction at other intracellular sites. Studies relating to the liver are few but suggest that calcium channel blockers may have a role to play in limiting hepatocellular damage, especially those arising from exposure to a variety of toxic agents. © 1991.

引用

页码：251 / 255

页数：5

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