CHANGES IN GLYCOLIPID EXPRESSION IN HUMAN TESTICULAR-TUMOR

被引：51

作者：

OHYAMA, C ^{[1
]}

FUKUSHI, Y ^{[1
]}

SATOH, M ^{[1
]}

SAITOH, S ^{[1
]}

ORIKASA, S ^{[1
]}

NUDELMAN, E ^{[1
]}

STRAUD, M ^{[1
]}

HAKOMORI, S ^{[1
]}

机构：

[1] BIOMEMBRANE INST,SEATTLE,WA 98119

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 06期

关键词：

D O I：

10.1002/ijc.2910450610

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glycolipids were extracted from testicular tumor tissues of 13 patients, and their pattern of expression compared with that of normal testicular tissue. The most conspicuous and consistent change in the tumor extracts was marked accumulation of CTH (ceramide trihexoside). Structural analysis by enzyme cleavage showed that CTH which accumulated in the tumor tissue was Gb3 (Galαl‐4Galßl‐4Glcßl‐Cer). Immunohistochemistry using anti‐Gb3 monoclonal antibody (MAb) (lA4) also indicated massive accumulation of Gb3 in the tumor tissue. Gb3 may be a new marker of testicular tumors, especially seminomas, for which useful markers are so far lacking. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1040 / 1044

页数：5

共 26 条

[1]

BREMER EG, 1986, J BIOL CHEM, V261, P2434

[2] DISIALOGANGLIOSIDES-GD2 AND GD3 ARE INVOLVED IN THE ATTACHMENT OF HUMAN-MELANOMA AND NEUROBLASTOMA-CELLS TO EXTRACELLULAR-MATRIX PROTEINS [J].