MIDAZOLAM COINDUCTION DOES NOT DELAY DISCHARGE AFTER VERY BRIEF PROPOFOL ANESTHESIA

被引：14

作者：

ELWOOD, T ^{[1
]}

HUCHCROFT, S ^{[1
]}

MACADAMS, C ^{[1
]}

机构：

[1] ALBERTA CANC BOARD, DEPT EPIDEMIOL & PREVENT MED, CALGARY, AB, CANADA

来源：

CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1995年 / 42卷 / 02期

关键词：

ANESTHETICS; INTRAVENOUS; PROPOFOL; MIDAZOLAM; ALFENTANIL; INTERACTIONS; DRUG; RECOVERY; ASSESSMENT; SURGERY; AMBULATORY;

D O I：

10.1007/BF03028262

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Previous reports have demonstrated synergism of midazolam and propofol for induction of anaesthesia in humans. We tested the hypothesis that in the presence of alfentanil, the combination of midazolam with propofol for a very brief operative procedure would not affect the recovery phase. During pre-oxygenation, 64 outpatients scheduled for dilatation and curettage received placebo, or low-dose midazolam (0.03 mg . kg(-1)) or high-dose midazolam (0.06 mg . kg(-1)) iv, in a randomized double-blind manner. They then received alfentanil 10 mu g . kg(-1) iv, followed by titrated doses of propofol iv for induction and maintenance of anaesthesia. Ventilation with 70% N2O in O-2 by mask was controlled to achieve a PETCO(2) 30-40 mmHg. Outcome measures were: propofol dose (induction and maintenance), time until eye-opening to command, and time to discharge-readiness. Propofol induction dose was decreased by increasing doses of midazolam (P = 0.00005). Midazolam delayed time to eye-opening (P = 0.02) but not time to discharge-readiness. This study had an 80% power to detect a 39 min difference in time to discharge-readiness. We conclude that midazolam propofol co-induction in the presence of alfentanil delays eye-opening, but does not delay discharge after anaesthesia.

引用

页码：114 / 118

页数：5

共 25 条

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