METHYLPREDNISOLONE REDUCES EXCITATORY AMINO-ACID RELEASE FOLLOWING EXPERIMENTAL SPINAL-CORD INJURY

被引：59
|
作者：
LIU, DX
MCADOO, DJ
机构：
[1] Marine Biomedical Institute, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston
来源：
BRAIN RESEARCH | 1993年 / 609卷 / 1-2期
关键词：
SPINAL CORD INJURY; EXCITATORY AMINO ACID; METHYLPREDNISOLONE; MICRODIALYSIS;
D O I：
10.1016/0006-8993(93)90885-Q
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Administration of methylprednisolone within several hours after injury to the spinal cord has been shown to reduce subsequent impairment in humans and experimental animals. Secondary damage following initial trauma is probably caused in part by the toxicity of released excitatory amino acids. We demonstrate here that methylprednisolone reduces the release of excitatory amino acids following experimental spinal cord injury in rats.
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页码：293 / 297
页数：5
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