PHARMACOKINETICS AND ORAL BIOAVAILABILITY OF HYDROCORTISONE

被引：143

作者：

DERENDORF, H ^{[1
]}

MOLLMANN, H ^{[1
]}

BARTH, J ^{[1
]}

MOLLMANN, C ^{[1
]}

TUNN, S ^{[1
]}

KRIEG, M ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,COLL MED,W-4630 BOCHUM,GERMANY

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 05期

关键词：

D O I：

10.1002/j.1552-4604.1991.tb01906.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of 20 mg hydrocortisone were studied after IV and oral administration. Endogenous hydrocortisone was suppressed by dexamethasone administration. Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half-life of 1.7 hr. The volume of distribution was 34 L. Oral bioavailability averaged 96%. Absorption was rapid, achieving maximum hydrocortisone levels of 300 ng/mL after 1 hour. Saliva levels were not proportional to plasma levels, but could be shown to reflect free, non-protein bound hydrocortisone concentrations in plasma.

引用

页码：473 / 476

页数：4

共 9 条

[1]

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