ANGIOGENIC ACTIVITY OF VITREOUS EXTRACT OBTAINED FROM RABBIT EYES WITH ENDOTOXIN-INDUCED UVEITIS

被引：1
|
作者：
NAVEH, N [1 ]
NUSSBAUM, A [1 ]
DESATNIK, H [1 ]
BARTOV, E [1 ]
机构：
[1] TEL HASHOMER GOVT HOSP,SACKLER SCH MED,CHAIM SHEBA MED CTR,GOLDSCHLEGER EYE INST,TEL HASHOMER,ISRAEL
来源：
OPHTHALMIC RESEARCH | 1995年 / 27卷 / 01期
关键词：
ANGIOGENESIS; LEUKOTRIENE B-4; PROSTAGLANDINS TYPE E(2); UVEITIS; CORNEA;
D O I：
10.1159/000267563
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The effect of rabbit vitreous with endotoxin-induced uveitis was investigated for its role in the modulation of rat corneal neovascularization (NV). Elvax pellets implanted into at cornea contained either uveitic vitreous, intact vitreous or Elvax alone. The latter two kinds of pellets did not elicit NV. Uveitic vitreous pellets caused, in 100% of eyes, a persistent NV with maximal growth on the 10th day post implantation. Prostaglandin E(2) and leukotriene B-4 levels in the uveitic rabbit vitreous at 36 h postendotoxin injection were 7- and 5-fold higher than baseline, respectively. Histopathologically, the neovascularized cornea showed a significant inflammatory reaction attributable to the uveitic vitreous extract.
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页码：23 / 31
页数：9
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