ANGIOGENIC ACTIVITY OF VITREOUS EXTRACT OBTAINED FROM RABBIT EYES WITH ENDOTOXIN-INDUCED UVEITIS

被引：1

作者：

NAVEH, N ^{[1
]}

NUSSBAUM, A ^{[1
]}

DESATNIK, H ^{[1
]}

BARTOV, E ^{[1
]}

机构：

[1] TEL HASHOMER GOVT HOSP,SACKLER SCH MED,CHAIM SHEBA MED CTR,GOLDSCHLEGER EYE INST,TEL HASHOMER,ISRAEL

来源：

OPHTHALMIC RESEARCH | 1995年 / 27卷 / 01期

关键词：

ANGIOGENESIS; LEUKOTRIENE B-4; PROSTAGLANDINS TYPE E(2); UVEITIS; CORNEA;

D O I：

10.1159/000267563

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The effect of rabbit vitreous with endotoxin-induced uveitis was investigated for its role in the modulation of rat corneal neovascularization (NV). Elvax pellets implanted into at cornea contained either uveitic vitreous, intact vitreous or Elvax alone. The latter two kinds of pellets did not elicit NV. Uveitic vitreous pellets caused, in 100% of eyes, a persistent NV with maximal growth on the 10th day post implantation. Prostaglandin E(2) and leukotriene B-4 levels in the uveitic rabbit vitreous at 36 h postendotoxin injection were 7- and 5-fold higher than baseline, respectively. Histopathologically, the neovascularized cornea showed a significant inflammatory reaction attributable to the uveitic vitreous extract.

引用

页码：23 / 31

页数：9

共 50 条

[1] Treatment of endotoxin-induced uveitis by topical application of cyclosporine a-loaded PolyGel™ in rabbit eyes
Alshamsan, Aws
Abul Kalam, Mohd
Vakili, Mohammad Reza
Binkhathlan, Ziyad
Raish, Mohammad
Ali, Raisuddin
Alturki, Turki A.
Nikouei, Nazila Safaei
Lavasanifar, Afsaneh
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 569
[2] The effect of endothelin receptor antagonists in the endotoxin-induced uveitis rabbit model
Karaca, Emine Esra
Uzun, Feyzahan
Dilekoz, Ergin
Fincan, Gokce Sevim Ozturk
Ercan, Sevim
Kul, Oguz
Bagriacik, Emin Umit
Or, Meral
CUTANEOUS AND OCULAR TOXICOLOGY, 2018, 37 (02) : 133 - 138
[3] Immunohistochemical studies on the endotoxin-induced uveitis
杨培增
中华医学杂志(英文版), 1998, (03) : 60 - 64
[4] Intra-vitreal injection of methotrexate in experimental endotoxin-induced uveitis in rabbit
Hasiri, Mohammad Abbaszadeh
Moghaddam, Effat Baghaei
Khalili, Mohammad Reza
Amini, Amin Hossein
Eghtedari, Masoomeh
Azizzadeh, Mohammad
Razmi, Hooman
VETERINARY RESEARCH FORUM, 2018, 9 (04) : 315 - 321
[5] Intravitreal infliximab in experimental endotoxin-induced uveitis
Hosseini, Hamid
Safaei, Akbar
Khalili, Mohammad R.
Nowroozizadeh, Behdokht
Eghtedari, Masoometh
Farvardin, Mohsen
Nowroozizadeh, Sarah
Tolide-Ie, Hamid R.
EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2009, 19 (05) : 818 - 823
[6] Lithospermum erythrorhizon Siebold & Zucc. extract reduces the severity of endotoxin-induced uveitis
Kang, Tae Kyeom
Le, Tam Thi
Kwon, Hyukjoon
Park, Geon
Kim, Kyung-A
Ko, Hyejin
Hong, Suhee
Lee, Wook-Bin
Jung, Sang Hoon
PHYTOMEDICINE, 2023, 121
[7] Synthetic lipid A-induced uveitis and endotoxin-induced uveitis - A comparative study
Hanashiro, RK
Fujino, Y
Gugunfu
Samura, M
Takahashi, T
Masuda, K
JAPANESE JOURNAL OF OPHTHALMOLOGY, 1997, 41 (06) : 355 - 361
[8] Amelioration of Endotoxin-Induced Uveitis in Rabbit by Topical Administration of Tacrolimus Proglycosome Nano-Vesicles
Garg, Vaidehi
Nirmal, Jayabalan
Riadi, Yassine
Kesharwani, Prashant
Kohli, Kanchan
Jain, Gaurav Kumar
JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 110 (02) : 871 - 875
[9] Captopril suppresses inflammation in endotoxin-induced uveitis in rats
Ilieva, Iliyana
Ohgami, Kazuhiro
Jin, Xue-Hai
Suzuki, Yukari
Shiratori, Kenji
Yoshida, Kazuhiko
Kase, Satoru
Ohno, Shigeaki
EXPERIMENTAL EYE RESEARCH, 2006, 83 (03) : 651 - 657
[10] ANALYSIS OF INTERLEUKIN-6 IN ENDOTOXIN-INDUCED UVEITIS
HOEKZEMA, R
MURRAY, PI
VANHAREN, MAC
HELLE, M
KIJLSTRA, A
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1991, 32 (01) : 88 - 95

← 1 2 3 4 5 →