STRUCTURE-ANTIMICROBIAL ACTIVITY RELATIONSHIPS OF ABIETANE DITERPENES FROM SALVIA SPECIES

被引：54

作者：

MOUJIR, L

GUTIERREZNAVARRO, AM

SANANDRES, L

LUIS, JG

机构：

[1] UNIV LA LAGUNA, INST BIOORGAN, CPNO ANTONIO GONZALEZ, E-38206 TENERIFE, SPAIN

[2] UNIV LA LAGUNA, DEPT MICROBIOL & BIOL CELLULAR, E-38206 TENERIFE, SPAIN

来源：

PHYTOCHEMISTRY | 1993年 / 34卷 / 06期

关键词：

SALVIA SP; LABIATAE; DITERPENES; ABIETANES; ANTIMICROBIAL; STRUCTURE-ACTIVITY;

D O I：

10.1016/S0031-9422(00)90834-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-one abietatriene diterpenes isolated from Salvia species were evaluated for antimicrobial activity against three strains of bacteria and one yeast. The results obtained show that the free catechol grouping is essential for antimicrobial activity against Gram-positive bacteria and that activity appears to be independent of the closing position of the lactone group in the class A compounds. If there was an extra hydroxyl group at C-6 or C-7, activity was reduced to less than a third, and a hydroxy-methylene group at C-16 also rendered the products ineffective. Compounds where the catechol grouping had been oxidized to a quinone exhibited enhanced activity.

引用

页码：1493 / 1495

页数：3

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