SYNTHESIS OF ALPHA-AZIDO AND ALPHA-AMINO AMIDES FROM N-[(METHYLSULFONYL)OXY] AMIDES

被引：18

作者：

HOFFMAN, RV

NAYYAR, NK

CHEN, WT

机构：

[1] Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 09期

关键词：

D O I：

10.1021/jo00061a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Effective new syntheses of 2-azido amides and 2-amino amides from N-(mesyloxy) amides 1 have been developed. 2-Azido amides are produced by treating 1 with sodium azide in the presence of 15-crown-5. 2-Amino amides result from the reaction of 1 with various amines. Regiochemical control in the preparation of 2-amino amides is possible by modulating the amine nucleophilicity by steric bulk.

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页码：2355 / 2359

页数：5

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