THE ACTIVITY AND SUBCELLULAR-DISTRIBUTION OF THE PEROXISOMAL ENZYME ACYL-COA OXIDASE IN HUMAN BLOOD-PLATELETS

被引：3

作者：

FARSTAD, M

BAKKEN, AM

BERGE, RK

机构：

[1] Laboratory of Clinical Biochemistry, University Hospital, University of Bergen

来源：

BIOCHEMICAL JOURNAL | 1992年 / 286卷

关键词：

D O I：

10.1042/bj2860829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peroxisomal enzyme acyl-CoA oxidase is localized in the 'dense-tubular-system-enriched fraction', probably identical with the endoplasmic reticulum, in human blood platelets. This localization is strongly different from the localization of catalase which seems to be a cytosolic enzyme, in agreement with Marcus, Zucker-Franklin, Safir & Ullman [(1966) J. Clin. Invest. 45, 14-28]. A localization of acyl-CoA oxidase in the endoplasmic reticulum seems to be in good accordance with the important role of peroxisomes in the metabolism of prostaglandins, as recently demonstrated by Diczfalusy, Kase, Alexson & Bjorkhem [(1991) J. Clin. Invest. 88, 978-984].

引用

页码：829 / 831

页数：3

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