BACILLOMYCIN L(C), A NEW ANTIBIOTIC OF THE ITURIN GROUP - ISOLATIONS, STRUCTURES, AND ANTIFUNGAL ACTIVITIES OF THE CONGENERS

Bacillomycin L(c), a new antifungal antibiotic of the iturin class, was isolated from a strain of Bacillus subtilis as a set of five five congeners. The structure as determined by chemical and spectrometric analyses has been shown to differ from that of bacillomycin L by sequence changes from aspartate-1 to asparagine-1 and from glutamine-5 to glutamate-5. The five congeners differ from each other only in the structure of the aliphatic side chain of the constituent beta-amino acid. The hydrophobicity of the beta-amino acid affects the antifungal activity of the congener, as activity increased in the order of increased congener retention on a reversed-phase HPLC column.