MECHANISM OF CITRININ-INDUCED DYSFUNCTION OF MITOCHONDRIA .4. EFFECT ON CA2+ TRANSPORT

被引：31

作者：

CHAGAS, GM ^{[1
]}

OLIVEIRA, MBM ^{[1
]}

CAMPELLO, AP ^{[1
]}

KLUPPEL, MLW ^{[1
]}

机构：

[1] FED UNIV PARANA,DEPT BIOQUIM,BR-81531990 CURITIBA,PARANA,BRAZIL

来源：

CELL BIOCHEMISTRY AND FUNCTION | 1995年 / 13卷 / 01期

关键词：

KIDNEY CORTEX AND LIVER MITOCHONDRIA; BHK-21 CULTURED CELLS; 2-OXOGLUTARATE AND PYRUVATE DEHYDROGENASES; CALCIUM TRANSPORT; CITRININ; MYCOTOXIN;

D O I：

10.1002/cbf.290130110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of citrinin on Ca2+ transport was studied in isolated kidney cortex and liver mitochondria, and baby hamster kidney cultured cells. The mycotoxin significantly inhibited the activity of 2-oxoglutarate and pyruvate dehydrogenases in both kidney cortex and liver mitochondria. Citrinin promoted a decrease in the velocity and in the total capacity of Ca2+ uptake, in both mitochondria. Apparently, citrinin acts by a mechanism similar to ruthenium red. In intact cultured cells, citrinin also had a preferential effect on mitochondrial Ca2+ fluxes. Citrinin promoted a marked decrease in the Ca2+ level in the mitochondrial matrix, whereas that of the extramitochondiral fraction became less affected. All the observed effects were dependent on the citrinin concentration.

引用

页码：53 / 59

页数：7

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