GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) REDUCES PANCYTOPENIA AFTER RESCUE THERAPY IN A PATIENT WITH HODGKINS LYMPHOMA

被引：0
作者：
PIACIBELLO, W
CAMASCHELLA, C
STERN, AC
AGLIETTA, M
机构：
[1] Department of Biomedical Sciences and Human Oncology, University of Torino, Torino
[2] Clinical Research Department, Sandoz Ltd., Basel
来源：
LEUKEMIA & LYMPHOMA | 1990年 / 3卷 / 01期
关键词：
Chemotherapy; GM-CSF; Lymphoma; Pancytopenia;
D O I：
10.3109/10428199009050976
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
After several relapses, a stage IV lymphocyte depletion Hodgkin Lymphoma patient, with a bone marrow progenitor compartment depleted by several courses of chemotherapy, received further combination chemotherapy which caused severe and long-lasting pancytopenia. Because of an objective degree of tumor regression, a second identical course was administered, followed by Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) in an attempt to accelerate bone marrow recovery. This led to a significantly shorter period of neutropenia and thrombocytopenia with no additional red blood cell and platelet transfusion requirements. Furthermore, the neutropenic phase was not accompanied by septic complications. It is suggested that patients with solid tumors, even with a severely compromised bone marrow after several chemotherapy courses, may benefit from GM-CSF administration after rescue chemotherapy. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：61 / 66
页数：6
相关论文
共 18 条
  • [1] Clark S.C., Kamen R., The human hemopoietic colony stimulating factors, Science, 236, pp. 1229-1237, (1987)
  • [2] Sieff C.A., Hemopoietic growth factors, Journal of Clinical Investigation, 79, pp. 1549-1557, (1987)
  • [3] Wong G.G., Witek J.S., Temple P.A., Wilkens K.M., Leary A.C., Luxenberg D.P., Jones S.S., Brown E.L., Kay R.M., Orr E.C., Shoemaker C.S., Golde D.W., Kaufman R.J., Hewich R.M., Wang E.A., Clark S.C., Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins, Science, 288, pp. 810-815, (1985)
  • [4] Sieff C.A., Emerson S.G., Donahue R.E., Nathan D.G., Wang E.A., Wong G.G., Clark S.C., Human recombinant granulocyte-macrophage colony stimulating factor: a multilineage hemopoietin, Science, 230, pp. 1171-1173, (1985)
  • [5] Kaushansky K., O'Hara P.J., Berkner K., Segal G.M., Hagen F.S., Adamson J.W., Genomic cloning, characterization and multilineage growth promoting activity of human granulocyte macrophage colony stimulating factor, Proceedings of the National Academy of Science (USA), 83, pp. 3101-3105, (1986)
  • [6] Messner H.A., Yamasaki K., Jamal N., Minden M.M., Yang Y.C., Wong G.G., Clark S.C., Growth of human hemopoietic colonies in response to recombinant gibbon interleukin-3. Comparison with human recombinant granulocyte and granulocyte macrophage colony stimulating factor, Proceedings of the National Academy of Science (USA), 84, (1987)
  • [7] Metcalf D., Begley C.G., Johnson G.R., Nicola N.A., Vadas M.A., Lopez A.F., Williams D.J., Wong G.G., Clark S.C., Wang E.A., Biological properties in vitro of a recombinant granulocyte macrophage colony stimulating factor, Blood, 67, pp. 37-45, (1986)
  • [8] Weisbart R.H., Golde D.W., Clark S.C., Wong G.C., Gasson J.C., Human granulocyte macrophage colony stimulating factor is a neutrophil activator, Nature, 314, (1985)
  • [9] Weiser W.Y., Van Niel A., Clark S.C., David J.R., Remold H.G., Recombinant human granulocyte macrophage colony stimulating factor activates intracellular killing of Leishmania Donovani by human monocyte derived macrophages, Journal of Experimental Medicine, 166, (1987)
  • [10] Fleishmann J., Golde D.W., Weisbart R.H., Gasson J.C., Granulocyte Macrophage Colony-Stimulating Factor enhances phagocytosis of bacteria by human neutroxhils, Blood, 68, (1986)
12