DOSIMETRY OF I-123 IOMAZENIL IN HUMANS

被引：11

作者：

VERHOEFF, NPLG

SOKOLE, EB

HENGST, D

STUBBS, JB

VANROYEN, EA

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT RADIAT SAFETY,1105 AZ AMSTERDAM,NETHERLANDS

[2] OAK RIDGE INST SCI & EDUC,OAK RIDGE,TN

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1993年 / 20卷 / 07期

关键词：

DOSIMETRY; I-123; RECEPTORS; BENZODIAZEPINE; FLUMAZENIL; IOMAZENIL;

D O I：

10.1007/BF00176551

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of I-123-IBZM for adults was estimated to be 0.033 mSv/MBq.

引用

页码：580 / 584

页数：5

共 19 条

[11] IMAGING OF [C-11]-LABELED RO 15-1788 BINDING TO BENZODIAZEPINE RECEPTORS IN THE HUMAN-BRAIN BY POSITRON EMISSION TOMOGRAPHY [J].

PERSSON, A ;

EHRIN, E ;

ERIKSSON, L ;

FARDE, L ;

HEDSTROM, CG ;

LITTON, JE ;

MINDUS, P ;

SEDVALL, G .

JOURNAL OF PSYCHIATRIC RESEARCH, 1985, 19 (04) :609-&

[12] INVIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR-BINDING IN HUMAN EPILEPTIC FOCI [J].

SAVIC, I ;

ROLAND, P ;

SEDVALL, G ;

PERSSON, A ;

PAULI, S ;

WIDEN, L .

LANCET, 1988, 2 (8616) :863-866

[13] EVALUATION OF A MULTICENTER STUDY WITH IOMAZENIL - A BENZODIAZEPINE RECEPTOR LIGAND [J].

SCHUBIGER, PA ;

HASLER, PH ;

BEERWOHLFAHRT, H ;

BEKIER, A ;

OETTLI, R ;

CORDES, M ;

FERSTL, F ;

DEISENHAMMER, E ;

DEROO, M ;

MOSER, E ;

NITZSCHE, E ;

PODREKA, I ;

RICCABONA, G ;

BANGERL, I ;

SCHOBER, O ;

BARTENSTEIN, P ;

VANRIJK, P ;

VANISSELT, JW ;

VANROYEN, EA ;

VERHOEFF, NPLG ;

HALDEMANN, R ;

VONSCHULTHESS, GK .

NUCLEAR MEDICINE COMMUNICATIONS, 1991, 12 (07) :569-582

[14]

VERHOEFF NPL, IN PRESS NUCL MED CO

[15]

VERHOEFF NPL, 1992, NUKLEARMED-NUCL MED, V28, P175

[16]

VERHOEFF NPLG, 1991, NUCL MED SUPPL, V27, P203

[17]

VERHOEFF NPLG, 1992, NUCL EMD S, V28, P179

[18]

1992, PRECRIPTION DRUGS HU, P221

[19]

1977, WHO TECHNICAL REPORT, V611

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