DOSIMETRY OF I-123 IOMAZENIL IN HUMANS

被引：11

作者：

VERHOEFF, NPLG

SOKOLE, EB

HENGST, D

STUBBS, JB

VANROYEN, EA

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT RADIAT SAFETY,1105 AZ AMSTERDAM,NETHERLANDS

[2] OAK RIDGE INST SCI & EDUC,OAK RIDGE,TN

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1993年 / 20卷 / 07期

关键词：

DOSIMETRY; I-123; RECEPTORS; BENZODIAZEPINE; FLUMAZENIL; IOMAZENIL;

D O I：

10.1007/BF00176551

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of I-123-IBZM for adults was estimated to be 0.033 mSv/MBq.

引用

页码：580 / 584

页数：5

共 19 条

[1] BENZODIAZEPINE RECEPTORS AND CEREBRAL BLOOD-FLOW IN PARTIAL EPILEPSY [J].

BARTENSTEIN, P ;

LUDOLPH, A ;

SCHOBER, O ;

LOTTES, G ;

SCHEIDHAUER, K ;

SCIUK, J ;

BEER, HF .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1991, 18 (02) :111-118

[2] POPULATION RADIATION ABSORBED DOSE FROM NUCLEAR-MEDICINE PROCEDURES IN THE NETHERLANDS [J].

BEEKHUIS, H .

HEALTH PHYSICS, 1988, 54 (03) :287-291

[3]

BEER HF, 1990, J NUCL MED, V31, P1007

[4] DOSE TO FETUS FROM RADIONUCLIDES IN BLADDER [J].

CLOUTIER, RJ ;

SMITH, SA ;

WATSON, EE ;

SNYDER, WS ;

WARNER, GG .

HEALTH PHYSICS, 1973, 25 (02) :147-161

[5]

DEY H M, 1991, Journal of Nuclear Medicine, V32, P1043

[6]

Haefely W E, 1989, Acta Anaesthesiol Belg, V40, P3

[7] EFFECTIVE DOSE EQUIVALENT FROM RADIOPHARMACEUTICALS [J].

JOHANSSON, L ;

MATTSSON, S ;

NOSSLIN, B .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1984, 9 (11) :485-489

[8]

LOEVINGER R, 1990, MIRD PRIMER ABSORBED

[9] POPULATION CHARACTERISTICS AND ABSORBED DOSE TO THE POPULATION FROM NUCLEAR-MEDICINE - UNITED-STATES - 1982 [J].

METTLER, FA ;

CHRISTIE, JH ;

WILLIAMS, AG ;

MOSELEY, RD ;

KELSEY, CA .

HEALTH PHYSICS, 1986, 50 (05) :619-628

[10] REGIONAL SPECIFIC BINDING OF [C-11] RO-15-1788 TO CENTRAL TYPE BENZODIAZEPINE RECEPTORS IN HUMAN-BRAIN - QUANTITATIVE-EVALUATION BY PET [J].

PAPPATA, S ;

SAMSON, Y ;

CHAVOIX, C ;

PRENANT, C ;

MAZIERE, M ;

BARON, JC .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (03) :304-313

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