EFFECT OF GLUTATHIONE DEFICIENCY ON THE POOL OF COA-GLUTATHIONE MIXED DISULFIDE IN ESCHERICHIA-COLI

被引：5
|
作者：
LOEWEN, PC [1 ]
机构：
[1] UNIV MANITOBA, DEPT MICROBIOL, WINNIPEG R3T 2N2, MANITOBA, CANADA
来源：
CANADIAN JOURNAL OF BIOCHEMISTRY | 1981年 / 59卷 / 05期
关键词：
D O I：
10.1139/o81-052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The formic acid extracts of several glutathione-deficient strains of E. coli were assayed for the presence of the mixed disulfide of CoA and glutathione, CoASSG. Strains deficient in .gamma.-glutamyl-cysteine synthase (EC 6.3.2.2) produced only CoA dimer.Strains deficient in glutathione synthase (EC 6.3.2.3) produced the mixed disulfide of CoA and the .gamma.-glutamyl-cysteine dipeptide. The pool size of total CoA in the cell did not change significantly even in the absence of glutathione.
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页码：379 / 382
页数：4
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