COMPLEXATION OF DOXORUBICIN WITH BETA-CYCLODEXTRINS AND GAMMA-CYCLODEXTRINS

被引：49

作者：

HUSAIN, N ^{[1
]}

NDOU, TT ^{[1
]}

DELAPENA, AM ^{[1
]}

WARNER, IM ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

APPLIED SPECTROSCOPY | 1992年 / 46卷 / 04期

关键词：

DOXORUBICIN; CYCLODEXTRIN; FLUORESCENCE; CIRCULAR DICHROISM; NUCLEAR MAGNETIC RESONANCE; ABSORBENCY;

D O I：

10.1366/0003702924124943

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The binding of beta- and gamma-cyclodextrins with the anti-cancer drug doxorubicin has been examined with the use of fluorescence and absorbance spectroscopy, circular dichroism measurements, and proton NMR spectroscopy. The stoichiometry of the complexes formed and their apparent formation constants have been estimated with the use of various approaches. The stoichiometries for both the beta-cyclodextrin-doxorubicin complex and the gamma-cyclodextrin-doxorubicin complex have been determined to be predominantly 1:1. The strength of the interaction of the drug with gamma-cyclodextrin is stronger than that with beta-cyclodextrin. The effect of varying the pH on the calculated formation constants of the complexes has also been investigated.

引用

页码：652 / 658

页数：7

共 36 条

[31] ENHANCEMENT OF BIOAVAILABILITY OF CINNARIZINE FROM ITS BETA-CYCLODEXTRIN COMPLEX ON ORAL-ADMINISTRATION WITH DEUTERIUM-L-PHENYLALANINE AS A COMPETING AGENT [J].