ANTIPROLIFERATIVE ACTIVITY OF RETINOIDS, INTERFERON ALPHA AND THEIR COMBINATION IN 5 HUMAN TRANSFORMED-CELL LINES

被引：101

作者：

FREY, JR ^{[1
]}

PECK, R ^{[1
]}

BOLLAG, W ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,PHARMACEUT RES,CH-4002 BASEL,SWITZERLAND

来源：

CANCER LETTERS | 1991年 / 57卷 / 03期

关键词：

ANTIPROLIFERATIVE EFFECT; INTERFERON ALPHA; RETINOIDS; COMBINATION THERAPY;

D O I：

10.1016/0304-3835(91)90161-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tretinoin, isotretinoin and acitretin were examined for their capacity to modulate the proliferation of the cell lines: HL-60 (acute promyelocytic leukemia), MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Retinoids inhibited proliferation to a varying extent in all 5 cell lines. The cytokine IFN-alpha had a significant antiproliferative effect only on HL-60, SCC4 and SCC15. The combination of retinoids with IFN-alpha led in all 5 cell lines to a more profound reduction in proliferation than either retinoids or IFN-alpha alone.

引用

页码：223 / 227

页数：5

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