LETHAL CHROMOSOMAL DELETIONS IN THE MOUSE, A MODEL SYSTEM FOR THE STUDY OF DEVELOPMENT AND REGULATION OF POSTNATAL GENE-EXPRESSION

被引：8

作者：

GLUECKSOHNWAELSCH, S ^{[1
]}

DEFRANCO, D ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT BIOL SCI,PITTSBURGH,PA 15260

来源：

BIOESSAYS | 1991年 / 13卷 / 11期

关键词：

D O I：

10.1002/bies.950131102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mechanisms involved in the regulation of development and its genetic control are receiving ever-increasing attention in studies of mammalian developmental genetics. The potential success of such studies is strongly enhanced by the availability of suitable systems of analysis. Such a system was identified in a series of radiation-induced chromosomal deletions at and around the albino (c) locus of the mouse associated with cell type-specific effects on liver differentiation. Their detailed study has aided the analysis of possible mechanisms of cell type-specific gene expression. As summarized in this review, the experimental results strongly suggest that specific trans-acting developmental regulatory genes are concerned with the differentiation of hormone-inducible expression of a cluster of hepatocyte specific structural genes mapping in different parts of the genome.

引用

页码：557 / 561

页数：5

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