Adjunctive perampanel for glioma-associated epilepsy

被引：27

作者：

Dunn-Pirio, Anastasie M. ^{[1
]}

Woodring, Sarah ^{[1
]}

Lipp, Eric ^{[1
]}

Herndon, James E., II ^{[2
]}

Healy, Patrick ^{[2
]}

Weant, Mallika ^{[3
]}

Randazzo, Dina ^{[1
]}

Desjardins, Annick ^{[1
]}

Friedman, Henry S. ^{[1
]}

Peters, Katherine B. ^{[1
]}

机构：

[1] Duke Univ, Dept Neurosurg, Med Ctr, Durham, NC 27710 USA

[2] Duke Univ, Dept Biostat, Med Ctr, Durham, NC 27710 USA

[3] Duke Univ, Dept Pharm, Med Ctr, Durham, NC 27710 USA

来源：

EPILEPSY & BEHAVIOR CASE REPORTS | 2018年 / 10卷

关键词：

Epilepsy; Seizure; Brain tumor; Glioma; Isocitrate dehydrogenase 1; Perampanel;

D O I：

10.1016/j.ebcr.2018.09.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy. We conducted a single-arm study of adjunctive perampanel for patients with focal-onset glioma-associated seizures. The most common related adverse events were fatigue and dizziness. Three out of 8 participants had self-reported seizure reduction and an additional 3 reported improved control. Of these 6, 5 had isodtrate dehydrogenase 1 mutant gliomas. We conclude that perampanel is safe for patients with glioma-related focal-onset epilepsy. Further study into the association between AMPA signaling, IDH1 status and seizures is warranted. (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：114 / 117

页数：4

共 10 条

[1] Human glioma cells induce hyperexcitability in cortical networks [J].

Campbell, Susan L. ;

Buckingham, Susan C. ;

Sontheimer, Harald .

EPILEPSIA, 2012, 53 (08) :1360-1370

[2] Mutant IDH1 and seizures in patients with glioma [J].

Chen, Hao ;

Judkins, Jonathon ;

Thomas, Cheddhi ;

Wu, Meijing ;

Khoury, Laith ;

Benjamin, Carolina G. ;

Pacione, Donato ;

Golfinos, John G. ;

Kumthekar, Priya ;

Ghamsari, Farhad ;

Chen, Li ;

Lein, Pamela ;

Chetkovich, Dane M. ;

Snuderl, Matija ;

Horbinski, Craig .

NEUROLOGY, 2017, 88 (19) :1805-1813

[3] Practice parameter: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors - Report of the Quality Standards Subcommittee of the American Academy of Neurology [J].

Glantz, MJ ;

Forsyth, PA ;

Recht, LD ;

Wen, PY ;

Chamberlain, MC ;

Grossman, SA ;

Cairncross, JG .

NEUROLOGY, 2000, 54 (10) :1886-1893

[4] Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas [J].

Hartmann, Christian ;

Meyer, Jochen ;

Balss, Joerg ;

Capper, David ;

Mueller, Wolf ;

Christians, Arne ;

Felsberg, Joerg ;

Wolter, Marietta ;

Mawrin, Christian ;

Wick, Wolfgang ;

Weller, Michael ;

Herold-Mende, Christel ;

Unterberg, Andreas ;

Jeuken, Judith W. M. ;

Wesseling, Peter ;

Reifenberger, Guido ;

von Deimling, Andreas .

ACTA NEUROPATHOLOGICA, 2009, 118 (04) :469-474

[5]

Heimisdottir SB, 2018, HIGH EXPRESSION CYST

[6] Neurocognitive functioning in adult WHO grade II gliomas: impact of old and new treatment modalities [J].

Klein, Martin .

NEURO-ONCOLOGY, 2012, 14 :17-24

[7] NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in D-2-hydroxyglutaric aciduria [J].

Kölker, S ;

Pawlak, V ;

Ahlemeyer, B ;

Okun, JG ;

Hörster, F ;

Mayatepek, E ;

Krieglstein, J ;

Hoffmann, GF ;

Köhr, G .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 16 (01) :21-28

[8] Analysis of pooled phase III trials of adjunctive perampanel for epilepsy: Impact of mechanism of action and pharmacokinetics on clinical outcomes [J].

Kwan, Patrick ;

Brodie, Martin J. ;

Laurenza, Antonio ;

FitzGibbon, Hannah ;

Gidal, Barry E. .

EPILEPSY RESEARCH, 2015, 117 :117-124

[9] Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas [J].

Neal, Andrew ;

Yuen, Tanya ;

Bjorksten, Andrew R. ;

Kwan, Patrick ;

O'Brien, Terence J. ;

Morokoff, Andrew .

JOURNAL OF NEURO-ONCOLOGY, 2016, 129 (02) :259-267

[10] Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations [J].

Vecht, Charles ;

Duran-Pena, Alberto ;

Houillier, Caroline ;

Durand, Thomas ;

Capelle, Laurent ;

Huberfeld, Gilles .

JOURNAL OF NEURO-ONCOLOGY, 2017, 133 (03) :603-607

← 1 →