THYROID-HORMONE INFLUENCE ON THE SUSCEPTIBILITY OF MICE TO AUDIOGENIC-SEIZURES

被引：69
作者：
SEYFRIED, TN
GLASER, GH
YU, RK
机构：
[1] Department of Neurology, Yale University, School of Medicine, New Haven
来源：
SCIENCE | 1979年 / 205卷 / 4406期
关键词：
D O I：
10.1126/science.451624
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enchanced by treatment with excess thyroxine. Copyright © 1979 AAAS.
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页码：598 / 600
页数：3
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