RATS WITH ANXIOUS OR NONANXIOUS TYPE OF EXPLORATORY-BEHAVIOR DIFFER IN THEIR BRAIN CCK-8 AND BENZODIAZEPINE RECEPTOR CHARACTERISTICS

被引:103
作者
HARRO, J
KIIVET, RA
LANG, A
VASAR, E
机构
[1] TARTU STATE UNIV,PSYCHOPHARMACOL LAB,TARTU 202400,ESTONIA,USSR
[2] TARTU STATE UNIV,HORMONAL REGULAT LAB,TARTU 202400,ESTONIA,USSR
关键词
Anxiety; Behavioral difference; Benzodiazepine inverse agonist; Benzodiazepine receptor; Cholecystokinin octapeptide agonist; Cholecystokinin octapeptide receptor; Elevated plus-maze; Rat;
D O I
10.1016/0166-4328(90)90121-T
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Rats with high and low exploratory activity in an elevated plus-maze model of anxiety were separated into subgroups termed 'non-anxious' and 'anxious' respectively according to the number of sectors the animals crossed and the total amount of time they spent in the open part of the plus-maze. The binding parameters of benzodiazepine and cholecystokinin octapeptide (CCK-8) receptors in frontal cortex and hippocampus of selected animals were studied and compared to an animal group representing the total mean scores and to home-cage controls. It was established that anxious rats had a significantly lower number of benzodiazepine receptors in frontal cortex as compared to non-anxious animals and in hippocampus as compared to home-cage controls. There was also a decreased number of CCK-8 receptors in hippocampus of anxious rats as compared to the non-anxious and control groups. Non-anxious animals had a significantly lower number of CCK-8 receptors in frontal cortex than anxious and control rats. Acute treatment of rats with anxiogenic benzodiazepine inverse agonist FG 7142 (10 and 20 mg/kg) did not influence benzodiazepine binding in brain regions under investigation but caused upregulation of CCK-8 receptor binding in frontal cortex. On the other hand, CCK-8 analogues caerulein and pentagastrin, administered in doses which inhibit exploratory activity in plus-maze (100 or 500 ng/kg respectively), decreased the number of benzodiazepine binding sites in rat frontal cortex if injected intraperitoneally but did not affect CCK-8 binding. The present findings indicate that benzodiazepine and CCK-8 receptor binding characteristics in brain undergo rapid and behaviourally specific changes during stressful events. © 1990.
引用
收藏
页码:63 / 71
页数:9
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