In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus

被引:29
作者
Rad, Javad Sharifi [1 ,2 ]
Alfatemi, Seyedeh Mahsan Hoseini [3 ]
Rad, Majid Sharifi [4 ]
Iriti, Marcello [5 ]
机构
[1] Zabol Univ Med Sci, Zabol Med Plants Res Ctr, Zabol, Iran
[2] Zabol Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Zabol, Iran
[3] Shiraz Univ Med Sci, Shiraz Med Sch, Dept Bacteriol & Virol, Shiraz, Iran
[4] Univ Zabol, Fac Nat Resources, Dept Range & Watershed Management, Zabol, Iran
[5] Milan State Univ, Dept Agr & Environm Sci, I-20133 Milan, Italy
关键词
1,1-diphenyl-2-picrylhydrazyl; antioxidant activity; methicillin-resistant Staphylococcus aureus; methicillin-sensitive Staphylococcus aureus; Staphylococcus aureus; Xanthium strumarium L;
D O I
10.4103/0257-7941.139050
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background and Aims: The excessive and repeated use of antibiotics in medicine has led to the development of antibiotic-resistant microbial strains, including Staphylococcus aureus whose emergence of antibiotic-resistant strains has reduced the number of antibiotics available to treat clinical infections caused by this bacterium. In this study, antioxidant and antimicrobial activities of methanolic extract of Xanthium strumarium L leaves were evaluated on methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) spp. Materials and Methods: Antiradical and antioxidant activities X. strumarium L. leaf extract were evaluated based on its ability to scavenge the synthetic 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and by the paired diene method, respectively, whereas the antimicrobial activity was assayed by the disc diffusion method. Statistical Analysis: Data were subjected to analysis of variance following an entirely random design to determine the least significant difference at P < 0.05 using SPSS v. 11.5. Results and Conclusions: The IC50 values of the extract were 0.02 mg/mL and 0.09 mg/mL for the antioxidant and DPPH-scavenging capacity, respectively. X. strumarium extract affected both methicillin-sensitive Staphylococcus aureus and MRSA, though antibacterial activity was more effective on methicillin-susceptible S. aureus spp. The antibacterial and antioxidant activities exhibited by the methanol extract may justify the traditional use of this plant as a folk remedy worldwide.
引用
收藏
页码:109 / 113
页数:5
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