A GENETIC-STUDY OF TOTAL IGE LEVELS IN THE AMISH

被引：45
|
作者：
MEYERS, DA
BIAS, WB
MARSH, DG
机构：
[1] JOHNS HOPKINS UNIV, GOOD SAMARITAN HOSP, SCH MED, DIV CLIN IMMUNOL, HOWARD HUGHES MED INST LAB, BALTIMORE, MD 21239 USA
[2] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV MED GENET, BALTIMORE, MD 21239 USA
来源：
HUMAN HEREDITY | 1982年 / 32卷 / 01期
关键词：
D O I：
10.1159/000153262
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Relevant to the investigation of genetic factors involved in allergic response is the mode of inheritance of IgE levels, an important factor in allergic disease. Serum total IgE levels in 208 Pennsylvania [USA], Amish individuals from 23 nuclear families were studied. Males had a significantly higher mean in IgE level than females. There was also a significant negative relationship between age and IgE levels. Segregation analysis was used to fit a major gene model to the age- and sex-adjusted data. The environmental model was rejected (.chi.2 = 41.12, P < 0.005). The Mendelian codominant model was not rejected (.chi.2 = 8.84, P .simeq. 0.03) and gave a better fit to the data than the Mendelian dominant or recessive model.
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页码：15 / 23
页数：9
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