LONG-LASTING POSTMORTEM VIABILITY OF HUMAN-IMMUNODEFICIENCY-VIRUS - A POTENTIAL RISK IN FORENSIC MEDICINE PRACTICE

被引:38
作者
DOUCERON, H
DEFORGES, L
GHERARDI, R
SOBEL, A
CHARIOT, P
机构
[1] HOP HENRI MONDOR,DEPT PATHOL NEUROPATHOL & FORENS MED,F-94000 CRETEIL,FRANCE
[2] HOP HENRI MONDOR,DEPT VIROL,F-94010 CRETEIL,FRANCE
[3] HOP HENRI MONDOR,DEPT IMMUNOL,F-94010 CRETEIL,FRANCE
关键词
HIV; AUTOPSY; POSTMORTEM; CONTAMINATION; BLOOD; EFFUSION;
D O I
10.1016/0379-0738(93)90093-P
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
To determine the time from death when an autopsy could be carried out without any risk of contamination by human immunodeficiency virus (HIV), we cultured HIV from serial samples of blood and liquid effusion, collected as long as possible alter death from refrigerated dead bodies of HIV-infected patients. Samples were cocultivated with stimulated normal human lymphocytes and viral replication was assessed by p24 HIV1 antigen ELISA determination and by reverse transcriptase HIV1 and HIV2 activity microassay. Viable HIV was isolated from blood obtained 16.5 days postmortem, from pleural liquid effusion obtained 13.8 days postmortem, and from pericardial liquid effusion obtained 15.5 days postmortem. Viral replication was in evidence in at least one sample from all nine patients of the study. The present study did not allow us to determine a time from death when an autopsy could be carried out without any risk of contamination by HIV. We conclude that postponement of autopsies does not eliminate occupational risk of contamination by HIV.
引用
收藏
页码:61 / 66
页数:6
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