The synthesis and SAR of a series of novel derivatives of N-aminoadenosine is described, along with their in vitro effects in biochemical assays. The rat brain A1 adenosine receptor binding of these compounds is very dependent upon the purine 2-substituent. The novel agonist, 2-chloro-N-[4-(phenylthio)-1-piperidinyl]adenosine, exhibits a K(i) value for A1 receptor binding of <1 nM.
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
GINERSOROLLA, A
OBRYANT, SA
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机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
OBRYANT, SA
NANOS, C
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机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
NANOS, C
DOLLINGER, MR
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机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
DOLLINGER, MR
BENDICH, A
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机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
BENDICH, A
BURCHENAL, JH
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机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
GINERSOROLLA, A
OBRYANT, SA
论文数: 0引用数: 0
h-index: 0
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
OBRYANT, SA
NANOS, C
论文数: 0引用数: 0
h-index: 0
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
NANOS, C
DOLLINGER, MR
论文数: 0引用数: 0
h-index: 0
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
DOLLINGER, MR
BENDICH, A
论文数: 0引用数: 0
h-index: 0
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College
BENDICH, A
BURCHENAL, JH
论文数: 0引用数: 0
h-index: 0
机构:Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College