SEPARATION OF SOME ENANTIOMERS AND DIASTEREOMERS OF PROPRANOLOL DERIVATIVES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：23

作者：

FACKLAM, C

MODLER, A

机构：

[1] Max-Planck-Gesellschaft, Arbeitsgruppe Asymmetrische Katalyse an der Universitat Rostock (in the Inst. fur Organische Katalys, 18055 Rostock

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 664卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)87009-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The separation of some propranolol analogues I into their enantiomers and diastereomers respectively, by HPLC succeeded with cellulose tris(3,5-dimethylphenylcarbamate) as a chiral stationary phase and hexane-alcohol and aqueous NaClO4-acetonitrile as mobile phases. Retention times and alpha values depend on the substituents R(1) and R(2). With non-aromatic substituents R(1) or R(2) the R-enantiomers are eluted first whereas with aromatic substituents the S-enantiomers, surprisingly, have shorter retention times. [GRAPHICS] ]

引用

页码：203 / 211

页数：9

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