PREGNANCY-SPECIFIC BETA-1 GLYCOPROTEIN (SP-I) IN MATERNAL SERUM AND AMNIOTIC-FLUID - PREECLAMPSIA, SMALL-FOR-GESTATIONAL-AGE FETUS AND FETAL DISTRESS

Pregnancy specific β1 glycoprotein (SP-1) levels have been suggested to correlate with certain obstetrical complications. We compared maternal serum SP-1 levels in normal pregnancies (N = 82), and pregnancies complicated by pre-eclampsia (N= 37), small for gestational age fetuses (N = 8) and fetal distress (N = 13). We also compared levels of this protein in mid-trimester amniotic fluid samples obtained from normal (N = 47) and small for gestational age fetuses (N = 25). Despite trends towards low maternal serum and amniotic fluid SP-1 values in complicated pregnancies, there were no statistically significant differences in their levels as compared with normal gestational age matched controls (P > 0.005). These data do not support the use of SP-1 values in clinical practice. © 1993, Baillière Tindall. All rights reserved.