FLUORINATED PYRIMIDINES AS TIGHT-BINDING INHIBITORS OF THYMIDYLATE SYNTHETASE

被引：67
作者：
DANENBERG, PV [1 ]
LOCKSHIN, A [1 ]
机构：
[1] UNIV SO CALIF,SCH MED,CTR COMPREHENS CANC,LOS ANGELES,CA 90033
来源：
PHARMACOLOGY & THERAPEUTICS | 1981年 / 13卷 / 01期
关键词：
D O I：
10.1016/0163-7258(81)90068-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：69 / 90
页数：22
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共 89 条
[31]  
GARRETT C, 1979, BIOCHEMISTRY, V18, P2789
[32]   FLUORINATED PYRIMIDINES .19. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B [J].
GOTTSCHLING, H ;
HEIDELBERGER, CH .
JOURNAL OF MOLECULAR BIOLOGY, 1963, 7 (05) :541-+
[33]   REACTION OF SODIUM BISULFITE WITH URACIL, CYTOSINE, AND THEIR DERIVATIVES [J].
HAYATSU, H ;
WATAYA, Y ;
KAI, K ;
IIDA, S .
BIOCHEMISTRY, 1970, 9 (14) :2858-&
[34]   ADDITION OF SODIUM BISULFITE TO URACIL AND TO CYTOSINE [J].
HAYATSU, H ;
WATAYA, Y ;
KAI, K .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (03) :724-&
[35]   SYNTHESES OF 5-TRIFLUOROMETHYLURACIL + 5-TRIFLUOROMETHYL-2-DEOXYURIDINE [J].
HEIDELBERGER, C ;
PARSONS, DG ;
REMY, DC .
JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) :1-+
[36]   SYNTHESES OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE [J].
HEIDELBERGER, C ;
PARSONS, D ;
REMY, DC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (18) :3597-&
[37]   FLUORINATED PYRIMIDINES, A NEW CLASS OF TUMOUR-INHIBITORY COMPOUNDS [J].
HEIDELBERGER, C ;
CHAUDHURI, NK ;
DANNEBERG, P ;
MOOREN, D ;
GRIESBACH, L ;
DUSCHINSKY, R ;
SCHNITZER, RJ ;
PLEVEN, E ;
SCHEINER, J .
NATURE, 1957, 179 (4561) :663-666
[38]   MEASUREMENT OF PROTEIN-BINDING PHENOMENA BY GEL FILTRATION [J].
HUMMEL, JP ;
DREYER, WJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1962, 63 (03) :530-&
[39]   STUDIES ON THE CONVERSION OF DEOXYURIDYLIC ACID TO THYMIDYLIC ACID BY A SOLUBLE EXTRACT FROM RAT THYMUS [J].
HUMPHREYS, GK ;
GREENBERG, DM .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1958, 78 (02) :275-287
[40]   THYMIDYLATE SYNTHETASE - F-19 NMR CHARACTERIZATION OF ACTIVE-SITE PEPTIDE COVALENTLY BOUND TO 5-FLUORO-2'-DEOXYURIDYLATE AND 5, 10-METHYLENETETRAHYDROFOLATE [J].
JAMES, TL ;
POGOLOTTI, AL ;
IVANETICH, KM ;
WATAYA, Y ;
LAM, SSM ;
SANTI, DV .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 72 (02) :404-410
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