PREPARATION AND INVITRO AND INVIVO EVALUATION OF QUINOLONES WITH SELECTIVE ACTIVITY AGAINST GRAM-POSITIVE ORGANISMS

被引：53

作者：

COOPER, CS

KLOCK, PL

CHU, DTW

HARDY, DJ

SWANSON, RN

PLATTNER, JJ

机构：

[1] Anti-infective Research Division, Abbott Laboratories, Illinois 60064-3500, Abbott Park

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 08期

关键词：

D O I：

10.1021/jm00086a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of quinolones were prepared which contained oximes or substituted oximes as replacements for the amine substituents normally found on the pyrrolidine or piperidine fragments of quinolone antibacterial agents. These substituents led to compounds that had selective activity against Gram-positive organisms. These compounds showed in vivo activity against Staphylococcus aureus. Only compound 29 had in vivo activity against Streptococcus pneumoniae.

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页码：1392 / 1398

页数：7

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