IDENTIFICATION OF INDUCIBLE DAMAGE-RECOGNITION PROTEINS THAT ARE OVEREXPRESSED IN HELA-CELLS RESISTANT TO CIS-DIAMMINEDICHLOROPLATINUM(II)

被引：68

作者：

CHAO, CCK

HUANG, SL

LEE, LY

LINCHAO, S

机构：

[1] CHANG GUNG MED COLL, DEPT MED, TAOYUAN 33332, TAIWAN

[2] ACAD SINICA, INST MOL BIOL, TAIPEI 11529, TAIWAN

来源：

BIOCHEMICAL JOURNAL | 1991年 / 277卷

关键词：

D O I：

10.1042/bj2770875

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two cis-diamminedichloroplatinum(II) (cisplatin)-inducible proteins [b130 (approximately 130 kDa) and b95 (approximately kDa)] in HeLa cells that recognize both the cisplatin-modified and u.v.-modified DNA were identified in this study. These damage-recognition proteins were overexpressed in cisplatin-resistant HeLa cells. The results suggest that the damage-recognition proteins are regulated in the cells in response to DNA damage, and they may be important for DNA repair and probably the emergence of cisplatin resistance.

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页码：875 / 878

页数：4

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